leukotriene d4 maxspec® standard

Leukotriene D4 (LTD4) is a potent pro-inflammatory mediator formed from arachidonic acid, a bronchoconstrictor, and induces osteoclast senescence.Leukotriene D4 induces transcriptional activity of potentially oncogenic genes and can be used in the study of asthma.

11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25% of the potency for contraction of guinea pig ileum, trachea, and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

Leukotriene D4-d5 is a deuterated form of Leukotriene D4. Leukotriene D4 is one of the components of the slow-reacting substance of anaphylaxis (SRS-A), produced from LTC4 by the metabolism of γ-glutamyl transpeptidase. It is the first cysteinyl leukotriene metabolite of LTC4. The bronchoconstriction and increased vascular permeability induced by Leukotriene D4 contribute to the pathogenesis of asthma and acute hypersensitivity reactions.