kynurenine

L-Kynurenine ((S)-Kynurenine) is an endogenous agonist of the tryptophan metabolite and the aromatic hydrocarbon receptor (AHR). L-Kynurenine can inhibit the proliferation of allogeneic T cells and increase the invasion of malignant U87 glioma cells into the collagen matrix.

D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.

3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.

L-Kynurenine-D4 (Standard) is a reference standard of L-Kynurenine-D4 intended for quantitative analysis, quality control, and related biochemical research applications. L-Kynurenine-d4 is a deuterated compound of L-Kynurenine, suitable for isotope tracing. L-Kynurenine is a metabolite of tryptophan and an endogenous agonist of the AHR.

Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) is a ketone and amino acid derivative with diverse biological functions, including vasodilatory, immunoregulatory, and neuromodulatory activities. It is a precursor for niacin and its aberrant production is linked to neurological disease-related cognitive deficits and depressive symptoms. This compound is overexpressed in certain cancer cell types and could potentially serve as a biomarker to assess cancer risk.

Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P

PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in several psychiatric and neurological

L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory [Treg] phenotype.

L-Kynurenine-13C4,15N-1 is L-Kynurenine labeled with 13C and 15N. It is a metabolite of L-tryptophan and acts as an agonist of the aryl hydrocarbon receptor (aryl hydrocarbon receptor).

L-Kynurenine-13C10 (sulfate hemihydrate) is a 13C-labeled form of L-Kynurenine sulfate. This compound acts as an aryl hydrocarbon receptor (AHR) agonist, facilitating the AHR-driven initial polarization of T cells towards an anti-inflammatory Treg phenotype.

L-Kynurenine-13C10 sulfate hydrate is the C13-labeled variant of L-Kynurenine sulfate hydrate. L-Kynurenine serves as an agonist for the aryl hydrocarbon receptor.

Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mamma

L-Kynurenine-d4 is a deuterated compound of L-Kynurenine. L-Kynurenine has a CAS number of 2922-83-0. L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.

L-Kynurenine-d4-1 hydrochloride is a deuterium-labeled version of L-Kynurenine. It is a metabolite of L-tryptophan and acts as an agonist for the aryl hydrocarbon receptor (aryl hydrocarbon receptor).

L-Kynurenine-d4-1 is a deuterated compound of L-Kynurenine. L-Kynurenine has a CAS number of 2922-83-0. L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.

L-Kynurenine (Standard) is a reference standard for research and analysis in studies involving L-Kynurenine. L-Kynurenine ((S)-Kynurenine) is an endogenous agonist of the tryptophan metabolite and the aromatic hydrocarbon receptor (AHR). L-Kynurenine can inhibit the proliferation of allogeneic T cells and increase the invasion of malignant U87 glioma cells into the collagen matrix.

3-Hydroxykynurenine-13C3,15N (3-Hydroxy-DL-kynurenine-13C3,15N) is a 3-Hydroxykynurenine compound labeled with 13C and 15N. It is a metabolite of tryptophan and acts as a potential endogenous neurotoxin, with increased levels observed in various neurodegenerative diseases. 3-Hydroxykynurenine induces neuronal apoptosis (apoptosis).

N-Formylkynurenine (Standard) is a reference standard for research and analysis in studies involving N-Formylkynurenine. N-Formylkynurenine, an intermediate in tryptophan catabolism, is a formyl derivative of kynurenine. Its formation is catalyzed by heme dioxygenases.

3-Hydroxykynurenine-13C3,15N (Standard) is a reference standard of 3-Hydroxykynurenine-13C3,15N intended for quantitative analysis, quality control, and related biochemical research applications.

N-Formylkynurenine, an intermediate in tryptophan catabolism, is a formyl derivative of kynurenine. Its formation is catalyzed by heme dioxygenases.

4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.