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Results for "
jnj28871063 hydrochloride
" in TargetMol Product Catalog- Inhibitors & Agonists1
JNJ28871063 hydrochloride
JNJ-28871063 hydrochloride, JNJ 28871063 hydrochloride
T22881944342-90-9
JNJ28871063 hydrochloride is an orally active, ATP-competitive, and highly selective pan-ErbB kinase inhibitor with IC50 values of 22 nM for ErbB1, 38 nM for ErbB2, and 21 nM for ErbB4, JNJ28871063 hydrochloride effectively inhibits phosphorylation of key tyrosine residues in EGFR and ErbB2, crossing the blood–brain barrier, and demonstrating antitumor efficacy in xenograft models overexpressing EGFR and ErbB2.
- $93
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