ivabradine hydrochloride

Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.

N-Demethyl Ivabradine HCl is a specific inhibitor of the funny channel and a metabolite of Ivabradine.

N-Demethyl Ivabradine-D6 hydrochloride is the deuterium labeled N-Demethyl Ivabradine Hydrochloride (T11695), which is a Ivabradine metabolite.

Ivabradine hydrochloride (Standard) is a reference standard for research and analysis in studies involving Ivabradine hydrochloride. Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.

Ivabradine-D3 hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine hydrochloride (TMSM-3413) is the deuterium labeled Ivabradine hydrochloride.

Ivabradine-D6 hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine D6 hydrochloride is the deuterium labeled Ivabradine hydrochloride (T2535).

N-Desmethyl Ivabradine-D6 hydrochloride is a deuterated compound of N-Desmethyl Ivabradine hydrochloride (T11695). N-Desmethyl Ivabradine hydrochloride has a CAS number of 1246638-08-3.