ivabradine

Ivabradine is a potent, orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits pacemaker current (If). ivabradine decreases heart rate in a dose-dependent manner and does not alter blood pressure. ivabradine has anticonvulsant, anti-ischaemic and anti-anginal effects.

Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.

Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine D3 Hydrochloride is the deuterium labeled Ivabradine hydrochloride.

Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine D6 hydrochloride is the deuterium labeled Ivabradine hydrochloride.

N-Demethyl Ivabradine HCl is a specific inhibitor of the funny channel and a metabolite of Ivabradine.

N-Demethyl Ivabradine D6 Hydrochloride salt is the deuterium labeled N-Demethyl Ivabradine, which is a Ivabradine metabolite.

8-Demethyl Ivabradine, a metabolite of Ivabradine, is an orally bioavailable cyclic nucleotide-gated (HCN) channel blocker with hyperpolarization-activated properties[1].

Ivabradine Impurity 1, identified as an impurity of Ivabradine, is an orally bioavailable compound that functions as a blocker of the hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel [1].

Ivabradine Impurity 2, an impurity of Ivabradine, is a compound known for its oral bioavailability and mechanism as a blocker of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels [1].

N-Desmethyl Ivabradine-d6 HCl is a deuterated compound of N-Desmethyl Ivabradine HCl. N-Desmethyl Ivabradine HCl has a CAS number of 1246638-08-3.