isrib

ISRIB is a potent and selective PERK inhibitor.

ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2α.

ISRIB-A15 (ISR-IN-2) is an potent inhibitor of the integrated stress response with an EC50 of 0.8 nM.

trans-isrib A17 (ISR-IN-1) is an potent inhibitor of the integrated stress response with EC50 of 0.6 nM.

ATF4-IN-1 (Compound 21) serves as an inhibitor of ATF4, demonstrating effective suppression of ATF4 expression in Thapsigargin-stimulated HEK-293T cells with an IC50 of 32.43 nM. Compared to ISRIB, ATF4-IN-1 shows enhanced activity and exhibits minimal cytotoxicity, with an IC50 of 96 μM in HEK-293T cells. This compound is utilized in the investigation of neurodegenerative diseases [1].