isotonicity

D-Sorbitol (Sorbitol) is a polyhydric alcohol with about half the sweetness of sucrose, occurring naturally and also produced synthetically from glucose. Formerly used as a diuretic, it may still be used as a laxative and in irrigating solutions for certain surgical procedures. It is also utilized in various manufacturing processes, as a pharmaceutical aid, and in several research applications.

L-Histidine buffer (Sterile) is a widely used antibody-storage formulation containing 20 mM L-Histidine, 240 mM sucrose, 150 mM NaCl, and 0.05% Tween-80 at pH 5.8. L-Histidine buffer (Sterile) supports long-term protein stability by providing osmoprotection, isotonicity, and controlled acidity, making it suitable for monoclonal antibody preservation and biologics development.