isap

Norcisapride is a 5-hydroxytryptamine receptor 3 (5-HT3) and (5-hydroxytryptamine receptor 4 (5-HT4) dual agonist used for the treatment of gastrointestinal disorders, orofacial disorders, and otorhinolaryngologic disorders.

Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.

Parisaponin I is a useful organic compound for research related to life sciences and the catalog number is T124652.

Yayoisaponin B is a useful organic compound for research related to life sciences. The catalog number is T125328 and the CAS number is 218934-74-8.

Abrisaponin A is a useful organic compound for research related to life sciences. The catalog number is T125550 and the CAS number is 178666-57-4.

4-O-Methylepisappanol is a useful organic compound for research related to life sciences and the catalog number is T126375.

3'-Deoxy-4-O-methylepisappanol is a useful organic compound for research related to life sciences and the catalog number is T126471.

Kakisaponin A is a useful organic compound for research related to life sciences. The catalog number is T126551 and the CAS number is 1003864-78-5.

Abrisaponin D1 is a useful organic compound for research related to life sciences and the catalog number is T128908.

Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.

Sisapronil is a member of the phenylpyrazole class of antiparasitics.

Justicisaponin I is a type of triterpenoid saponin from Justicia simplex D. Don. (Acanthaceae).

Norcisapride belongs to the class of organic compounds known as diphenylpyrroles. Norcisapride acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Norcisapride is a metabolite of cisapride.

Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports of heart rhythm abnormalities and these led to 80 deaths. Other reported adverse effects are: headache, diarrhea, abdominal pain, nausea, constipation. Cisapride for animals has been found helpful in some cases of megaesophagus and is a common treatment for feline megacolon. Clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride. Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be e......

Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).

Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.

Onjisaponin Z is a natural product known as a triterpenoid saponin, characterized by its molecular structure that includes a sapogenin (aglycone) attached to one or more sugar moieties. Commonly found in the root of the medicinal herb Polygala tenuifolia, Onjisaponin Z exhibits a range of pharmacological effects, such as neuroprotective, anti-inflammatory, and antioxidant activities.

Onjisaponin A is a natural product.

Azukisaponin II, a natural saponin extracted from adzuki beans (Vigna angularis L.), exhibits antiviral activity against herpes and possesses antioxidant properties.

Azukisaponin VI, an oligosaccharide glycoside isolated from Vigna angularis, exhibits activity in inhibiting the synthesis of peroxylipids. This compound is utilized in research related to hyperlipidemia.

Onjisaponin Y is a natural product that can be used in related research in the field of life sciences. Its product number is TN8481.

I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.