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By Target- IRE1
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Results for "
ire1α kinase activity
" in TargetMol Product Catalog- Inhibitors & Agonists3
GSK2850163
T114882121989-91-9In house
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α), effectively inhibiting both its RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
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IRE1α kinase-IN-1
T95642328097-41-0
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM, displaying 100-fold selectivity over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, as well as IRE1α RNase activity (IC50=80 nM).
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