ip5k

Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.

PIP5K1C-IN-1 (Compound 30) is a potent PIP5K1C inhibitor with an IC50 of 0.80 nM. In mice, it exhibits low total clearance and high kinase selectivity, making it useful for research in cancer and chronic pain.

PIP5K1C-IN-2 (compound 33) is a potent and selective inhibitor of 4-phosphate 5-kinase 1 C (PIP5K1C) with an IC50 value of 0.0059 µM.

PIP5K1α-IN-1 (Compound 3e) is an inhibitor of phosphatidylinositol 4-phosphate 5-kinase type I alpha (PIP5K1α), with an IC50 of 0.46 μM.