i sap

I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.

Norcisapride is a 5-hydroxytryptamine receptor 3 (5-HT3) and (5-hydroxytryptamine receptor 4 (5-HT4) dual agonist used for the treatment of gastrointestinal disorders, orofacial disorders, and otorhinolaryngologic disorders.

Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.

Parisaponin I is a useful organic compound for research related to life sciences and the catalog number is T124652.

Mi-Saponin B is a useful organic compound for research related to life sciences. The catalog number is T124683 and the CAS number is 54328-43-7.

Mi-Saponin A is a useful organic compound for research related to life sciences. The catalog number is T124684 and the CAS number is 54328-42-6.

Yayoisaponin B is a useful organic compound for research related to life sciences. The catalog number is T125328 and the CAS number is 218934-74-8.

Abrisaponin A is a useful organic compound for research related to life sciences. The catalog number is T125550 and the CAS number is 178666-57-4.

4-O-Methylepisappanol is a useful organic compound for research related to life sciences and the catalog number is T126375.

3'-Deoxy-4-O-methylepisappanol is a useful organic compound for research related to life sciences and the catalog number is T126471.

Kakisaponin A is a useful organic compound for research related to life sciences. The catalog number is T126551 and the CAS number is 1003864-78-5.

Abrisaponin D1 is a useful organic compound for research related to life sciences and the catalog number is T128908.

Ferroptosis/apoptosis inducer-2 (compound D2) is an anticancer drug that has demonstrated anticancer activity both in vivo and in vitro.

Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.

Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.

Sisapronil is a member of the phenylpyrazole class of antiparasitics.

Justicisaponin I is a type of triterpenoid saponin from Justicia simplex D. Don. (Acanthaceae).

Norcisapride belongs to the class of organic compounds known as diphenylpyrroles. Norcisapride acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Norcisapride is a metabolite of cisapride.

Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports of heart rhythm abnormalities and these led to 80 deaths. Other reported adverse effects are: headache, diarrhea, abdominal pain, nausea, constipation. Cisapride for animals has been found helpful in some cases of megaesophagus and is a common treatment for feline megacolon. Clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride. Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be e......

Olezarsen, an N-acetyl-galactosamine-conjugated antisense oligonucleotide, targets hepatic APOC3 mRNA to inhibit the production of apolipoprotein C-III (apoC-III), thereby lowering triglyceride levels in patients who are at high risk for or have established cardiovascular disease.

Olezarsen sodium, an N-acetyl-galactosamine-conjugated antisense oligonucleotide, targets hepatic APOC3 mRNA to suppress the production of apolipoprotein C-III (apoC-III). This action helps reduce triglyceride levels in patients at high risk for or with established cardiovascular disease.

Ferroptosis/apoptosis inducer-1 (compound 4d) acts as a dual inducer of both cell apoptosis (apoptosis) and iron-dependent cell death (ferroptosis). It promotes these processes by decreasing mitochondrial membrane potential and downregulating GPX4. Effective in vitro and in vivo, Ferroptosis/apoptosis inducer-1 significantly inhibits the proliferation and metastasis of triple-negative breast cancer (TNBC), playing a crucial role in cancer research.

Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).

Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.