ht 61

HT-61, a pyrroloquinolone antibiotic, is used potentially for the treatment of staphylococcal infections.

AVN-101 is a highly potent 5-HT7 receptor antagonist with a Ki value of 153 pM. AVN-101 also exhibits considerable affinity for histamine H1 (Ki value of 0.58 nM) and adrenergic α2A, α2B and α2C (Ki values ​​of 0.41-3.6 nM) receptors. AVN-101 has shown good oral bioavailability and brain-blood barrier permeability, low toxicity and reasonable efficacy in animal models of central nervous system diseases.

hVEGF-IN-3 (compound 9) serves as an effective inhibitor of hVEGF. It inhibits the proliferation of HT-29, MCF-7, and HEK-293 cells with IC50 values of 61, 142, and 114 μM, respectively.

lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM).