hpb

HPB is a selective HDAC6 deacetylase inhibitor

MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.

PHPB-D7 is a deuterated compound of PHPB.

HP-β-CD (HP-β-CD) is a widely used drug delivery vehicle to improve stability and bioavailability.

DHP-B exhibits anticancer properties and can induce apoptosis. It forms a covalent bond with the Cys96 of CPT1A, obstructing FAO and disrupting the interaction between mitochondrial CPT1A and vdac1. This results in increased mitochondrial permeability in CRC cells, along with reduced oxygen consumption and energy metabolism. DHP-B can be isolated from the plant Peperomia dindygulensis.

Robinin (NSC-9222) belongs to natural products, serving as a TLR2 inhibitor with cell permeability. Robinin exerts anti-inflammatory and antitumor activities through inhibiting the TLR2-PI3K-AKT pathway, and can be used for experimental research related to pancreatic cancer.

Nipamovir is a nitroimidazole prodrug. In cell-based assay systems and ex vivo models of human HIV infection, Nipamovir exhibits antiviral activity similar to that of SAMT-247 and NS-1040 with lower cytotoxicity. For the two systems of CEM-SS/HIV-1RF and hPBMC/HIV-192HT599, the EC50 values of Nipamovir are 3.64±3.28 μM and 3.23±2.81 μM, respectively.

(R,S)-N-Nitrosoanabasine (NAB) is a tobacco-specific N-nitrosamine (TSNA) identified in tobacco products and electronic cigarettes. It inhibits the cytochrome P450 (CYP) isoform CYP2A13 metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) into 4-oxo-4-(3-pyridyl) butanal (OPB), 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB), and 4-oxo-4-(3-pyridyl) butanoic acid (OPBA), with respective Ki values of 0.23, 0.87, and 0.5 µM. While NAB is not carcinogenic in hamsters, it is carcinogenic in mice.

Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM). Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM. It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.