headache

(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural compound derived from the roots and rhizomes of Notopterygium incisum.

Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that suppresses HDAC1 activity and induces HDAC2 degradation, exhibiting oral bioavailability. Valproic Acid activates Notch1 signalling and inhibits the proliferation of small cell lung carcinoma cells, making it applicable for research into epilepsy and bipolar disorder.

Oxyresveratrol 4-O-β-D-glucopyranoside (Compound 3) is a natural product extracted from the root bark of *Morus atropurpurea*, with potential applications in research on diabetes, arthritis, rheumatism, cough, and headache [1].

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.

(-)-Fargesol is a nartural product from the flowers buds of Magnolia fargesii,the dried flower buds of M. fargesii, has been used as therapy for nasal empyema and headache.