haemolytic

CspA Protein, Staphylococcus haemolyticus, Recombinant (His) is expressed in E. coli. The accession number is Q4L6A7.

Expression system: E. coli
Length: 1-267, Full Length
Activity: Not Tested

Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.