h1993

MK-8033 is a new and selective dual ATP competitive c-Met Ron inhibitor (IC50: 1 nM Wt c-Met).

Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinase inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptors.

DFX117 is an orally effective selective inhibitor of PI3Kα and c-Met tyrosine kinase (c-Met). This compound inhibits the PI3K Akt mTOR pathway and suppresses the proliferation of NCI-H1975, NCI-H1993, and HCC827 cells, with IC50 values ranging from 0.02 to 0.08 µM. Additionally, DFX117 induces cell cycle arrest in the G0 G1 phase and triggers apoptosis (apoptosis) in A549 and NCI-H1975 cells. It also exhibits antitumor activity in mice.