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- VEGFR(1)
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Results for "
gsk 1363089
" in TargetMol Product Catalog- Inhibitors & Agonists2
- PROTAC Products1
Foretinib
GSK089, EXEL-2880, GSK1363089, XL880
T3113849217-64-7
Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.
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SJF 8240
T362462230821-68-6
c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.
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