glur5 receptor

Topiramate-D12 is a deuterium labeled Topiramate. Topiramate (T0675) is an agent of broad-spectrum antiepileptic. Topiramate (T0675) is an antagonist of GluR5 receptor.

LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors.

LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.

ATPA is a selective glutamate receptor GluR5 activator (EC50s: 0.66, 1.4, 9.5, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S721T), GluR5(S741M), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V)).

GluR5-containing kainate receptor antagonist

5-Iodowillardiine is a selective agonist for specific kainate receptor subunits that robustly activates GluK1 (GluR5) and GluK5 (KA2)-containing receptors while displaying minimal activity at AMPA receptors and no measurable agonism toward GluK2 (GluR6) subunits. Despite its excitotoxic neurotoxic activity in vivo, 5-Iodowillardiine remains a powerful experimental tool for dissecting kainate receptor subtype distribution, synaptic function, and excitatory neurotransmission in the brain and spinal cord.

GluR5-subunit containing kainate receptor antagonist

UBP310 (UBP 310) is a GLUK5 kainate receptor antagonist

LY339434 is a potent and selective agonist of the kainate receptor, specifically targeting GluK1 and GluR5.

Topiramate lithium (McN 4853) is a broad-spectrum antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action includes enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3]

Topiramate-13C6 is the 13C labeled form of Topiramate. Topiramate (T0675) (McN 4853) serves as a broad-spectrum antiepileptic agent. It functions as a GluR5 receptor antagonist and exhibits anticonvulsant effects by enhancing GABAergic activity, inhibiting kainate/AMPA receptors, blocking voltage-sensitive sodium and calcium channels, increasing potassium conductance, and inhibiting carbonic anhydrase.