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globomycin

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Globomycin
TP214467076-74-8
Globomycin, a lipopeptide antibiotic, is an inhibitor of signal peptidase II (LspA). It binds irreversibly to the peptidase, thereby inhibiting the processing of the prolipoprotein.
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Globomycin derivative G2A
TP3617
Globomycin derivative G2A (Compound G2A) is an inhibitor of lipoprotein signal peptidase II (LspA), with an IC50 of 604 nM. It exhibits inhibitory activity against E. coli, P. aeruginosa, and A. baumannii, displaying minimum inhibitory concentrations (MIC) ranging from 12.5 to 32 μg/mL.
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