gfp

N1-Methylpseudouridine (1-Methylpseudouridine) is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density in mRNA.

GFP11 is a protein fusion tag composed of 16 amino acids. It facilitates the presentation of proteins on the outer membrane of Gram-negative bacteria and emits green fluorescence by complementing with externally added GFP1-10. Due to its small molecular weight, GFP11 does not significantly affect protein solubility or expression, nor does it alter the catalytic activity of the enzyme CsBglA. GFP11 is applicable in creating a split GFP system for high-throughput biotechnology and flow cytometry applications.

Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.

Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.

RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM.

eGFP mRNA-LNP (500 ng/uL) is a lipid nanoparticle (LNP) containing eGFP mRNA, suitable for assays of RNA delivery, translation efficiency, and cell viability. eGFP circRNA includes the Enhanced Green Fluorescent Protein (eGFP), which expresses green fluorescent protein upon entering cells. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry.

Enhanced Green Fluorescent Protein (EGFP) (200-208) is a peptide that strongly binds to H2-K, a restricted cytotoxic T lymphocyte (CTL) epitope.

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.

eGFP mRNA-LNP is a lipid nanoparticle encapsulating eGFP mRNA, designed to evaluate RNA delivery, translation efficiency, and cell viability. Upon cell internalization, it expresses Enhanced Green Fluorescent Protein (eGFP), enabling detection through fluorescence microscopy or flow cytometry [1].

eGFP mRNA encodes the green fluorescent protein, originally derived from the jellyfish Aequorea victoria, and serves as a widely utilized direct detection reporter in mammalian cell culture. This protein produces a distinct bright green fluorescence, with an emission peak at 509 nm.

eGFP circRNA-LNP, a lipid nanoparticle comprising eGFP circRNA, facilitates studies of RNA delivery, translation efficiency, and cell viability. This compound includes Enhanced Green Fluorescent Protein (eGFP) for expression within cells, detectable via fluorescence microscopy or flow cytometry [1].

eGFP(cy5) mRNA is a chemically modified synthetic mRNA designed for high-sensitivity tracking of gene delivery processes. The compound features a dual-functional design: its nucleotide sequence encodes the enhanced Green Fluorescent Protein (eGFP) to quantify translation efficiency, while the mRNA backbone is covalently labeled with the near-infrared fluorophore Cy5. This dual-labeling system enables researchers to distinguish the physical distribution of mRNA (uptake/endocytosis, visualized as Cy5 red signal) from its functional biological activity (protein expression, visualized as eGFP green signal) at the single-cell level. It is widely utilized in lipid nanoparticle (LNP) formulation optimization, endocytic pathway elucidation, and tissue distribution studies.

C-Fos Lentiviral CDNA ORF Clone, Human, C-GFPSpark Tag is an ORF clone of the FOS plasmid, where Fos encodes a leucine zipper protein and forms the transcription factor complex AP-1, which regulates cell proliferation, differentiation, and transformation.

EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.

Eeyarestatin I is an inhibitor that inhibits the degradation and translocation of ER-associated proteins. Eeyarestatin I is associated with the p97 deubiquitination process and inhibits atx3 deubiquitination. Eeyarestatin I has anticancer effects by inducing proteins that cause cell death.

KG-FP-003 is a highly effective, selective, and durable TEAD PROTAC degrader featuring degradation concentrations of TEAD1DC50= 6 ± 4 nM, TEAD2DC50= 68 ± 15 nM, TEAD3DC50= 12 ± 5 nM, and TEAD4DC50= 7 ± 5 nM. It facilitates the ubiquitination and degradation of TEAD and exhibits anticancer activity against mesothelioma and ovarian cancer.

Integrase-LEDGF/p75 allosteric inhibitor 1 is an orally active inhibitor that targets integrase-LEDGF/p75 (IN-LEDGF/p75), impeding HIV-1 DNA integration and exhibiting antiviral effects against the HIV-1 recombinant molecular clone NL432 with an EC50 of 3.9 nM.

RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of hmvecs (ec50 = 420 nm).

KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.

Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).

Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches, strongly inhibiting GFP expression with a 50% effective concentration (EC50: 0.3 μM).

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC, comprising the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker, that induces the degradation of GFP-HaloTag7 in cell-based assays[1].

(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC based VHL ligand and a 3-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].