fumagillin

Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.

Cis-Fumagillin methyl ester inhibits both MetAP2 and MetAP1.

Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.

PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.

Fumagillol is a direct precursor of the potent angiogenesis inhibitors [TNP-470] and (fumagillin).