forkhead box m1(foxm1)

OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.

Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis.

RCM-1 is an inhibitor of FOXM1.

ARF(26–44), cell-permeable is an anti-tumor peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein. It serves as an inhibitor of FoxM1, a forkhead box M1 transcription factor, and has demonstrated significant anti-tumor activity in the treatment of mouse hepatocellular carcinoma (HCC). This activity includes increasing apoptosis and reducing tumor cell proliferation and angiogenesis. ARF(26–44), cell-permeable is useful for research in cancer therapy.