fibrinogen

Fibrinogen is a heterodimeric protein that can be cleaved by thrombin. Fibrinogen is a potential marker for cardiovascular disease and plays an important role in metabolism. Its absence can cause fibrinogenemia.

Bovine fibrinogen (from fibrinogen) is a natural fibrinogen derived from bovine plasma. It can modulate the activation of NF-KB in endothelial cells and upregulate the expression of the inflammatory chemokine MCP-1.

Fibrinogen (from human plasma) is suitable for preparing production factor solutions.

Fibrinogen from rat plasma can be used for the preparation of growth factor solutions.

Heparin (Nadroparin) calcium (MW 3600-5000), an anticoagulant, forms a reversible complex with antithrombin III (ATIII), known as the heparin-antithrombin III complex. This complex then irreversibly binds to and inactivates thrombin and other activated clotting factors IX, X, XI, and XII, thereby inhibiting the conversion of fibrinogen to fibrin [1] [2].

Bemiltenase alfa is a hemostatic agent that targets coagulation factor X (FX). It activates FX to facilitate the conversion of prothrombin into thrombin, which subsequently transforms fibrinogen into fibrin, thereby forming a stable blood clot and exerting its hemostatic effect. Bemiltenase alfa shows potential for research in bleeding symptoms associated with hemophilia.

Nonacog gamma is a coagulation factor IX (FIX) supplement that activates factor X (FX), facilitating the generation of thrombin, which then converts fibrinogen into fibrin to form a stable blood clot and exert hemostatic effects. Nonacog gamma holds potential for research in the treatment of hemophilia B.

Human Tenascin is a glycoprotein capable of forming hexamers linked by disulfide bonds. It consists of repeated domains, including EGF-like repeats, fibronectin type III repeats, and regions homologous to fibrinogen. Human Tenascin is applicable for cell culture.