erd 308

ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).ERD-308 is a highly potent PROTAC degrade

(S,R,S)-AHPC-Me-amide-C-O-C5-Br is a compound that includes a VHL ligand for recruiting E3 ubiquitin ligase, along with a linker. This compound is utilized in the synthesis of various PROTAC molecules, such as [ERD-308].

tert-Butyl 2-((5-bromopentyl)oxy)acetate is a PROTAC linker (PROTAClinker) used in the synthesis of ERD-308.