epoxomicin

Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate.

Biotin-epoxomicin is a biotin-labeled form of epoxomicin. It acts as a high-affinity probe targeting the proteasome (Proteasome) and is capable of covalently binding to various proteasome catalytic subunits, such as LMP7, Z, and MECL1.

Biotin-(Oaa)3-epoxomicin (Compound 13) is the biotinylated active form of Epoxomicin. It serves as a high-affinity probe targeting the proteasome. Biotin-(Oaa)3-epoxomicin can covalently bind to multiple proteasome catalytic subunits, such as LMP7, Z, and MECL1.