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  • EGFR
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egfr (e746_a750)

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  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
WZ-3146
T67331214265-56-1
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
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Almonertinib
HS-10296
T54621899921-05-1
Almonertinib (HS-10296) is an inhibitor specifically targeting EGFR activation mutations and the resistant EGFR T790M mutation, exhibiting limited activity against wild-type EGFR.
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wz4002
T62381213269-23-8
WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM 8 nM.
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WZ8040
T67341214265-57-2
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
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