dna vaccines

SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv

ODN 1826 is a 20-mer DNA strand, a TLR9 agonist and an immunostimulant, with anti-tumor and cardioprotective effects, promoting apoptosis, and stimulating the production of NO and iNOS. ODN 1826 is a CpG DNA mimetic that can be used as an adjuvant for synthetic vaccines.

DSPE-PEG-NHS (MW 3400), a pegylated phospholipid derivative, is utilized in the formulation of liposomes or lipid nanoparticles within targeted drug delivery systems, including DNA or mRNA vaccines.

DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

DSPE-PEG-NHS, MW 2000, is a PEGylated phospholipid derivative utilized in the preparation of liposomes for the delivery of DNA or mRNA vaccines.

VC1052 is a component of HY-142998 Vaxfectin. Vaxfectin is a cationic lipid adjuvant used for vaccines based on plasmid DNA and proteins.

DSPE-PEG-azide (MW 5000) is a click chemistry reactive phospholipid polyPEG capable of forming lipid bilayers or micelles in aqueous solutions. This polymer is suitable for creating liposomes or nanoparticles intended for the delivery of nutrients or therapeutic agents, such as mRNA or DNA vaccines. It is of reagent grade and intended for research use only.

DSPE-PEG-Ald, MW 5000, is a phospholipid PEG polymer with a hydrophilic head oriented towards water (micelle), allowing it to spontaneously self-assemble in aqueous environments. It is utilized in forming liposomes for drug nanocarriers, applicable in delivering nutrients and therapeutic agents, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde group can react with aminooxy groups to form stable oxime linkages or with amines at pH < 7 to create reversible imine bonds. This compound is available as reagent grade, for research use only.

DSPE-PEG-OH, MW 5000, is a linear phospholipid PEG polymer. The lipid tail permits the encapsulation of hydrophobic therapeutic agents, while the PEG chain maintains its hydrophilicity. This polymer can be utilized in drug nanocarriers, such as liposomal anticancer drugs or mRNA DNA vaccines. It is reagent grade and intended solely for research purposes.

DSPE-PEG-SPDP, MW 1000, is a thiol-reactive PEG lipid. This amphiphilic polymer spontaneously forms lipid bilayers in water. It is employed for encapsulating nutrients or therapeutics for targeted drug delivery, such as mRNA or DNA vaccines, or liposomal doxorubicin for anti-tumor applications. Reagent grade, for research use only.

DSPE-PEG-Vinylsulfone, MW 3400 is a thiol-reactive PEG lipid. This polymer spontaneously self-assembles in aqueous solutions to form lipid bilayers and can be used to prepare nanoparticles or liposomes for drug delivery applications, such as mRNA vaccines or DNA vaccines. Reagent grade, for research use only.

DSPE-PEG-Vinylsulfone, MW 5000, is a vinyl sulfone PEG lipid that can undergo bio-conjugation with cysteine or other thiol molecules through a thiol-ene reaction. This polymer serves as a self-assembling agent, forming lipid bilayers in water and is utilized as a drug carrier for delivering therapeutic agents like mRNA or DNA vaccines. Reagent grade, intended for research use only.

DSPE-PEG-NHS, MW 600, is a PEG-modified phospholipid derivative used in liposome preparation for the delivery of DNA or mRNA vaccines.

DSPE-m-PEG-NHS (MW 3400) is a PEGylated phospholipid derivative employed in the preparation of liposomes for the delivery of DNA or mRNA vaccines.