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dhcr 7

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
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AY 9944
T14362366-93-8In house
AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Δ7-Δ8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3β-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
  • $35
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1-(2,3-Dichlorphenyl)-piperazine
DCPP
T2099941202-77-1
1-(2,3-Dichlorphenyl)-piperazine (DCPP) is a potent DHCR7 inhibitor. DHCR7 is the last enzyme in cholesterol biosynthesis.
    7-10 days
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