dextran sulfate sodium salt (mw 36000-50000)

Dextran sulfate sodium salt (MW 36,000–50,000) is a medium molecular weight polyanionic dextran derivative with strong intestinal epithelial permeability. It is the most commonly used agent for inducing inflammatory bowel disease (IBD) models, effectively inducing both acute and chronic colitis. Its mechanism may involve macrophage dysfunction and gut microbiota dysbiosis. Due to its colonic epithelial toxicity, long-term use can also induce colorectal cancer models.

Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. It exhibits antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Additionally, Dextran sulfate sodium salt can be utilized as an additive in cell culture media to prevent cell clumping and as a gel-forming agent in cosmetic products.