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desmethyl bosentan

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Desmethyl Bosentan
T37351253688-61-8
Desmethyl bosentan, an active metabolite of the endothelin receptor antagonist bosentan, activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay at a concentration of 25 μM.
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Hydroxy desmethyl Bosentan
Ro 64-1056
T11584253688-62-9
Hydroxy desmethyl Bosentan (Ro 64-105) is a metabolite of Bosentan formed by the liver cytochrome P450 enzymes CYP2C9 and CYP3A4.
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