dbco peg3 amine

DBCO-PEG3-amine, a PEG-based linker for PROTACs, joins two essential ligands and facilitates the formation of PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Sulfo DBCO-PEG3-acid is a click chemistry reagent featuring an azide group. This compound is an analog of DBCO-acid, equipped with a PEG linker and a DBCO moiety. The DBCO group, known for its strain-promoted high-energy state, is commonly utilized in copper-free click reactions. The hydrophilic polyethylene glycol chain and the sulfonyl group enhance its water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (such as EDC or HATU) to form stable amide bonds. This reagent is for research use only and is of reagent grade.

Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent featuring an azide group. It serves as an analog of DBCO-acid, incorporating a PEG linker and a DBCO group. The DBCO group is often utilized in copper-free click reactions due to its high-energy strain. The hydrophilic polyethylene glycol chain and sulfo group enhance its water solubility. The terminal carboxylic acid can react with primary amine groups to form stable amide bonds in the presence of activators such as EDC or HATU. This is a reagent-grade compound intended solely for research purposes.