creatinine

Creatinine (NSC-13123) is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

4-Hydroxytryptamine creatinine sulfate, a derivative of tryptamine, acts as an agonist for neurotransmitters.

Creatinine-D3 is a deuterium-labeled Creatinine (T0496) which is a break-down product of creatine phosphate in muscle.

5-Hydroxytryptamine creatinine sulfate monohydrate (Serotonin creatinine sulfate monohydrate) is a neurotransmitter.

α,α,β,β-D4-Serotonin-Creatinine Sulfate Complex H2O (Standard) is a reference standard of α,α,β,β-D4-Serotonin-Creatinine Sulfate Complex H2O intended for quantitative analysis, quality control, and related biochemical research applications. α,α,β,β-d4-Serotonin-Creatinine Sulfate Complex H2O is a deuterated compound of α,α,β,β-Serotonin-Creatinine Sulfate Complex H2O.

Creatinine-D5 (Standard) is a reference standard of Creatinine-D5 intended for quantitative analysis, quality control, and related biochemical research applications. Creatinine-d5 is a deuterated compound of Creatinine. Creatinine has a CAS number of 60-27-5. Creatinine is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

Creatinine-D3 (Standard) is a reference standard of Creatinine-D3 intended for quantitative analysis, quality control, and related biochemical research applications.

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.

N-Methylhydantoin (1-Methyl-hydantoin) is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. In mammals, the Metabolism of N-Methylhydantoin occurs via 5-hydroxy-1-methylhydantoin. In a reported human case,N-Methylhydantoin was found as an unexpected metabolite of the intelligence-affecting substance dupracetam.

Creatininase (CAH) is a homohexameric enzyme found in Pseudomonas putida, which can be used in the study of biosensors for creatinine assays and chronic renal failure.

Creatinine amidohydrolase [Pseudomonas sp. (EC 3.5.2.10)] catalyzes the hydrolysis of creatinine to form creatine.

Creatinine Phosphate Disodium Salt is a useful organic compound for research related to life sciences and the catalog number is T125448.

Creatinine-D5 is a deuterated compound of Creatinine. Creatinine (T0496) has a CAS number of 60-27-5. Creatinine (T0496) is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

α,α,β,β-D4-Serotonin-Creatinine Sulfate Complex H2O is a deuterated compound of α,α,β,β-Serotonin-Creatinine Sulfate Complex H2O.

Creatinine-13C is a 13C-labeled form of creatinine. Creatinine (T0496) (NSC13123) is the breakdown product of phosphocreatine found in muscle.

Creatinine (Standard) is a reference standard for research and analysis in studies involving Creatinine. Creatinine (NSC-13123) is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson's disease.

HTBA is a low-cost enzymatic paper-based analytical device (enz-PAD) for determining urine creatinine.

5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

Creatine (Methylguanidoacetic acid) is an amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. Creatine functions as part of the cell's energy shuttle. The high energy phosphate group of ATP is transferred to creatine to form phosphocreatine in the following reaction: Cr + ATP <-> PCr + ADP. This reaction is reversibly catalyzed by creatine kinase. In the human body, creatine is synthesized mainly in the liver by the use of parts from three different amino acids: arginine, glycine, and methionine. 95% of it is later stored in the skeletal muscles and the rest is stored in the brain, heart, and testes.

Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibits anti-inflammatory effects. Methyl

Levoglucosan (1,6-anhydro-b-D-Glucose) is an anhydrohexose that is the 1,6-anhydro-derivative of beta-D-glucopyranose. It is formed from the pyrolysis of carbohydrates, such as starch and cellulose. Levoglucosan can also be utilized in the synthesis of chiral polymers such as unhydrolysable glucose polymers. Levoglucosan is also produced via caramelization of sugar. Consumption of caramel or caramel-containing sweets can lead to a short-term 5X increase in urinary levels of levoglucosan (from 20 uM/mM creatinine to 100 uM/mM creatinine).

NAD Synthetase is responsible for the final step in the synthesis of Nicotinamide Adenine Dinucleotide (NAD). The enzyme sourced from Escherichia coli exhibits Km values of 200 μM for NAD, 11 μM for ATP, and 0.65 μM for ammonia. Conversely, NAD Synthetase derived from yeast demonstrates Km values of 170 μM for NAD, 190 μM for ATP, and 64 μM for ammonia. This enzyme is applicable in enzymatic assays for ATP, ammonia, urea, or creatinine and can also be used in enzymatic recycling methods. Additionally, NAD Synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative disorders.

Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.