control compound

GSK8573 is an inactive control compound for GSK2801, with binding activity to BRD9 (Kd of 1.04 μM).

Milenperone (R 34009) is a novel anti-invasive compound designed to control behavioral disorders in patients with epilepsy and alcoholism.

MS 154N is a negative control for MS 154. The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kdvalues are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

Chloroxylenol (PCMX) (4-chloro-3, 5-dimethylphenol), a broad spectrum antimicrobial chemical compound, is used to control virus, bacteria, fungi, and algae. It is used in households and hospitals for sanitation and disinfection.

N-Phenethylacetamide is an amide derivative of phenethylamine that can be used as a reference standard for quality control and analytical testing, and it can also be employed as an effective antimicrobial agent for use in aquaculture systems.

Trometamol hydrochloride (TRIS hydrochloride) (Tromethamine hydrochloride) is a biologically inert amino alcohol with low toxicity. Trometamol hydrochloride buffers carbon dioxide and acids in vitro and in vivo. Trometamol hydrochloride is an effective amine compound for pH control in the physiological range.

m-Tolualdehyde is a natural aromatic aldehyde exhibiting inhibitory effects against Tyrophagus putrescentiae (Schrank), rendering it suitable for mite control.

CL-278474 (compound I-79) is a potent inhibitor of β-N-acetylhexosaminidase OfHex1. CL-278474 can be used in control of insect.

BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705, a GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM, used in acute myeloid leukemia [AML] studies.

(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block and ligand used as a negative control for (S,R,S)-AHPC. It is based on VH032 and is employed in the recruitment of the VHL protein.

Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.

Antifungalagent 117 is a bipyrrole carboxamide derivative with antifungal activity, exhibiting an EC50 value of 11.58 mg L against Sclerotinia sclerotiorum. This compound induces cell death by increasing cell membrane permeability, causing an imbalance in osmotic pressure between the interior and exterior of the cell. It also promotes oxidative damage to the cell membrane by inducing the accumulation of reactive oxygen species (ROS), leading to the leakage of cellular contents. RNA sequencing analysis has demonstrated that Antifungalagent 117 disrupts cell membrane structure by downregulating catalase genes and upregulating neutral ceramidase genes, accelerating ceramide metabolism and hastening cell death. The compound holds significant potential for application in plant protection and the control of fungal infections.

EA-89-Succinic acid (Compound 26) serves as an active control ligand for the target protein of PROTAC. It is also utilized in the synthesis of QA-68.

FFAR1 FFAR4 agonist-1 (compound 83) is an agonist targeting both FFAR1 and FFAR4, with EC50 values of 1 nM and 4 nM respectively. This compound is used in research for glycemic control.

Methfuroxam is a systemic fungicide that effectively inhibits Basidiomycetes pathogens. This compound is also utilized in the control of loose smut and Rhizoctonia solani, and is commonly used as a seed treatment agent.

Simufilamum (also known as PTI-125) is an oral small-molecule compound candidate that targets altered conformations of filamin A. It binds and reverts the misfolded filamin A in the brains of Alzheimer's disease patients, thereby slowing the disease's pathological progression. Additionally, PTI-125 reduces tau protein hyperphosphorylation, decreases Aβ42 aggregation and deposition, neurofibrillary tangles, and neuroinflammation. The compound demonstrates concentration-dependent efficacy in vitro, starting at 1 picomolar (pM), in both control groups and post-mortem hippocampal slices from Alzheimer's disease (AD) patients. PTI-125 is the first therapeutic candidate to preferentially bind and reverse pathogenic protein conformations.

WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new therapeutics.

Antiangiogenic agent 8 (Compound 3m) functions as both an antibacterial agent and an antiangiogenic compound. It shows minimum inhibitory concentrations (MIC) of 16, 8, 4, 16, and 8 μg mL against E. coli, P. aeruginosa, B. subtilis, S. aureus, and C. glabrata, respectively, with minimum bactericidal concentrations (MBC) ranging from 32 to 64 μg mL. This compound holds potential for applications in infection control and cardiovascular disease research.

Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.

SDH-IN-24 (Compound 51) is an inhibitor of succinate dehydrogenase (SDH) with an LC50 of 6.9 mg/L against second-stage larvae of Bursaphelenchus xylophilus and an IC50 of 15.0 μM against SDH. It exerts nematicidal activity by disrupting nematode energy metabolism, inhibiting movement, feeding, reproduction, inducing oxidative stress, reducing protein content, and impairing antioxidant capability. SDH-IN-24 is applicable for research in nematode control.

SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.

Antifungalagent 129 (Compound 4g) acts as an inhibitor against Rhizoctonia solani, with an EC50 value of 4.27 mg/L. It shows effective control of rice sheath blight in both in vitro and in vivo studies. Preliminary investigations using scanning electron microscopy, molecular docking, enzyme activity assays, and cytotoxicity tests suggest that Antifungalagent 129 may exert its inhibitory action by affecting the cell structure or physiological processes of Rhizoctonia solani. This compound has potential applications in agricultural research related to plant diseases caused by Rhizoctonia solani, such as rice sheath blight.

mTORligand 1 (compound T2) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). It serves as an active control for the target protein ligand MHY1485 of PD-M6.

UNC4219 is a negative control compound for UNC3866, a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains.