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cl2-sn-38

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  • Inhibitors & Agonists
    3
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  • PROTAC Products
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    TargetMol | PROTAC
CL2-SN-38
T108321036969-20-6
CL2-SN-38, a part of the antibody-drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is an inhibitor of DNA topoisomerase I.
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7-10 days
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CL2 Linker
T177302270986-66-6
CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1 2 ~20 hours)[1][2].
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CL2-MMT-SN38
CL2-MMT-SN38
T384741084888-82-3
CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.
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