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(2)
By Target- PAD
- Apoptosis(1)
- MicroRNA(1)
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By Target By ResearchField- Cancer(1)
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Results for "
cl amidine tfa
" in TargetMol Product Catalog- Inhibitors & Agonists2
BB-Cl-Amidine TFA
T206893
BB-Cl-Amidine (TFA) is an inhibitor of peptidylarginine deiminase (PAD).
- Inquiry Price
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Cl-amidine TFA
T10831L21043444-18-3
Cl-amidine TFA is an orally active PAD inhibitor with IC₅₀ values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3 and PAD4, respectively. This compound can induce cancer cell apoptosis, and also upregulate the expression of miR-16 (miRNA-16, microRNA-16), thereby triggering cell cycle arrest. In addition, Cl-amidine TFA can block the citrullination of histone 3 and the formation of neutrophil extracellular traps, effectively improving the survival rate of mice with sepsis.
- $39
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