ckitin1

c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).

c-Kit-IN-10 (Compound 1) is an inhibitor of c-Kit. It is useful in research related to inflammation and malignant cancers, such as asthma.

c-Kit-IN-11 (Compound A7) is a c-Kit inhibitor with an IC50 of 76 nM against Mo7e cells. This compound is applicable for research in inflammatory conditions like asthma and malignant cancers.

c-Kit-IN-14 (Compound 1) is a c-kit kinase inhibitor. It effectively inhibits the phosphorylation of wild-type c-kit, with an IC50 value of 0.4 nM for pKIT. Additionally, c-Kit-IN-14 inhibits Exon 11 KIT with an IC50 value of 0.4 nM. This compound is applicable in the research of mast cell-mediated diseases, such as urticaria.

c-Kit-IN-12 (Compound 2a) is a potent c-Kit inhibitor with an IC50 of less than 10 nM across four KIT mutant cell models [BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, EX11 DEL/V654A]. It is useful for research into c-Kit-associated diseases or disorders, such as cancer.

c-Kit-IN-13 (Compound I) is an inhibitor of the c-kit kinase. It suppresses the autophosphorylation of the wild-type c-kit, with an IC50 of 0.3 nM for pKIT. Additionally, c-Kit-IN-13 inhibits Exon 11 KIT with an IC50 of 0.9 nM. This compound can be utilized in research on mast cell-mediated diseases such as urticaria.

(S)-c-Kit-IN-12 (Compound 2b) is a potent c-Kit inhibitor with an IC50 of less than 10 nM against four KIT mutant cell models [BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, EX11 DEL/V654A]. This compound is useful for researching diseases or disorders related to c-Kit, such as cancer.