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ci898

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  • Inhibitors & Agonists
    1
    TargetMol | Inhibitors_Agonists
Trimetrexate
CI-898
T1716452128-35-5
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.
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6-8 weeks
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Trimetrexate glucuronate
T6398582952-64-5
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist that inhibits dihydrofolate reductase, blocking the synthesis of purine nucleotides and thymidylic acid, therefore affecting DNA and RNA synthesis and exhibiting potential anti-tumour effects.
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6-8 weeks
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CI-898 HCl
T703041658520-97-8
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
  • $1,520
6-8 weeks
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