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By Target- Potassium Channel
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Results for "
c-3001a
" in TargetMol Product Catalog- Inhibitors & Agonists2
BE-16627B
T70834137530-61-1
BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 microM.
- $1,520
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QTY
(±)-C3001a
Cyclopentanecarboxylic acid, 3-[[[4-(6-methyl-2-benzothiazolyl)phenyl]amino]carbonyl]-, 3-[[[4-(6-Methyl-2-benzothiazolyl)phenyl]amino]carbonyl]cyclopentanecarboxylic acid, (RS)-C3001a
T719551374325-56-0
(±)-C3001a is the racemic mixture of C3001a (CAS: 2415154-29-7). C3001a is a selective activator of the TREK channel within the two-pore-domain potassium channel (K2P) family. C3001a specifically binds to a cryptic site formed by P1 and TM4 in TREK-1, thereby promoting the selective regulation of TREK-1 activity. C3001a targets TREK channels in the peripheral nervous system, reducing the excitability of pain-sensing neurons.
- $293
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