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bmy42393

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
BMY-42393
T70865136451-58-6
BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM). BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM). Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. BMY 42393 competed for radiolabeled iloprost and PGE1 binding to platelet membranes (IC50; 170 nM and 130 nM, respectively).
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8-10 weeks
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SR 27388
T70863136468-89-8
SR 27388 is an antioxidant and PAF receptor antagonist.
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6-8 weeks
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