bis-propargyl-peg-6

Bis-propargyl-PEG6 is a polyethylene glycol (PEG) derivative commonly employed as a PEG-based PROTAC linker during the synthesis of PROTACs. Its application includes the generation of polymer-linked multimers of guanosine-3', 5'-cyclic monophosphates[1].

Amino-PEG4-bis-PEG3-propargyl functions as a cleavable 6-unit PEG ADC linker in the creation of antibody-drug conjugates (ADCs) [1]. As a click chemistry reagent, it features an Alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with Azide-containing molecules.