biomarker

1,3,7-Trimethyluric acid, a purine alkaloid, occurs as a minor metabolite of caffeine in humans. It functions as an antioxidant with the ability to scavenge hydroxyl radicals and offers protective benefits against lipid peroxidation in erythrocyte membranes.

Formiminoglutamic acid (NSC 334078) is a biomarker for formylaminoglutaminuria, an indicator of folate deficiency.

Lathosterol, a molecule akin to cholesterol, serves as a biomarker for the body's total cholesterol synthesis, as indicated by its serum concentration.

2-Hydroxyphenylacetic acid (Ortho-Hydroxyphenylacetic acid) can be found in a number of food items such as natal plum, lemon verbena, half-highbush blueberry, and parsley, which makes 2-Hydroxyphenylacetic acid a potential biomarker for the consumption of these food products. 2-Hydroxyphenylacetic acid (Ortho-Hydroxyphenylacetic acid) can be found primarily in blood, feces, and urine.

1H-Indole-3-carboxaldehyde (3-Formylindole), also known as 3-formylindole or 3-indolealdehyde, belongs to the class of organic compounds known as indoles. Indoles are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole. 1H-Indole-3-carboxaldehyde is an extremely weak basic (essentially neutral) compound (based on its pKa). Outside of the human body, 1H-Indole-3-carboxaldehyde has been detected, but not quantified in, several different foods, such as gram beans, brussel sprouts, cucumbers, cereals and cereal products, and white cabbages. This could make 1H-indole-3-carboxaldehyde a potential biomarker for the consumption of these foods. A heteroarenecarbaldehyde that is indole in which the hydrogen at position 3 has been replaced by a formyl group.

5'-Guanylic acid disodium salt (GMP-5) is a purine ribonucleoside monophosphate. L-Glutamic acid and guanosine monophosphate are biosynthesized from xanthylic acid and L-glutamine via GMP synthase [glutamine-hydrolyzing]. Guanosine triphosphate and guanosine monophosphate are biosynthesized from diguanosine tetraphosphate via bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. In humans, guanosine monophosphate is involved in the kanamycin, telithromycin, tobramycin, and erythromycin action pathways, and several metabolic disorders including AICA-ribosiduria, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and 2-hydroxyglutric aciduria (D and L form) pathways. Guanosine monophosphate is also found in foods like onion-family vegetables, millet, Chinese water chestnut, and red rice, serving as a potential biomarker for the consumption of these foods.

D-(+)-Xylose (Wood sugar) is an aldopentose - a monosaccharide containing five carbon atoms and an aldehyde functional group. It has chemical formula C5H10O5 and is 40% as sweet as sucrose. Xylose is also found in mucopolysaccharides of connective tissue and sometimes in the urine. Xylose is the first sugar added to serine or threonine residues during proteoglycan type O-glycosylation. Therefore xylose is involved in the biosythetic pathways of most anionic polysaccharides such as heparan sulphate and chondroitin sulphate. In medicine, xylose is used to test for malabsorption by administering a xylose solution to the patient after fasting. If xylose is detected in the blood and or urine within the next few hours, it has been absorbed by the intestines. Xylose is said to be one of eight sugars which are essential for human nutrition, the others being galactose, glucose, mannose, N-acetylglucosamine, N-acetylgalactosamine, fucose, and sialic acid. . Xylose in the urine is a biomarker for the consumption of apples and other fruits.

Indole-3-methanamine has been detected, but not quantified in, barley, cereals, and cereal products.

Methionine sulfoxide, an oxidation product of methionine formed through interaction with reactive oxygen species, serves as a biomarker for oxidative stress in vivo.

N-Methylsarcosine (Dimethylglycine) is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role in the development of glycine-based ionic liquids and emulsifiers.

L-Arabinitol (L-(-)-Arabitol) is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean. L-Arabinitol is associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency.

1-Hydroxypyrene (1-Pyrenol), a biomarker of exposure to polycyclic aromatic hydrocarbons, is analyzed in urine samples.

Trans-Aconitic acid is normally present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase (EC 2.1.

N-Acetyl-L-arginine (Ac-Arg-OH), an N-acyl-L-alpha-amino acid with a strong basic nature (based on its pKa), has elevated serum levels in hyperargininemic patients and is associated with several diseases, including uremia and colorectal cancer. In untreated hyperargininemic patients, it reaches its highest levels in cerebrospinal fluid. It has also been detected in apples and loquats, suggesting it could be a potential biomarker for consumption of these foods. Additionally, a low-arginine diet combined with sodium benzoate therapy leads to a marked decrease in plasma N-acetyl-L-arginine concentrations.

3,5-Dihydroxybenzoic acid is a metabolite of alkylresorcinols in human urine and plasma, a potential biomarker of food intake such as beer, nuts, peanuts, and legumes, and a selective hydroxycarboxylic acid 1 (HCA1) inhibitor.

1,3,5-Trimethoxybenzene (Phloroglucinol trimethyl ether) is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.

D-(-)-Tartaric acid (D-Tartaric acid; (S, S)-tartarate; D-threaric acid) is mainly located in the cytoplasm. D-(-)-Tartaric acid can be converted into (2S,3S)-cis-fertaric acid and (2S,3S)-trans-fertaric acid. Outside the human body, it can be found in vinegar. This makes it a potential biomarker for the consumption of this food.

2-Hydroxybutyric acid (α-Hydroxybutyric acid) is a product of protein metabolism and serves as a biomarker for type 2 diabetes and pre-eclampsia.

Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German camomile, endive, and kiwi, which makes quercitrin a potential biomarker for the consumption of these food products.

Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation. Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 μM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.

L-(+)-Abrine (L-N-Methyltryptophan) is a toxic protein found in the jequirity seed.,can be used as a biomarker for abrin exposure.

8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-Hydroxyguanine is mutagenic and carcinogenic and is commonly used in cancer experiments.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.

24(S)-hydroxy Cholesterol (24S-OHC) is the terminal product of the cholesterol elimination pathway in neural tissues. It is an LXR agonist and a selective positive allosteric modulator of NMDARs. It can serve as a biomarker for NPD, induce cognitive decline in mice, and is useful for studying neurological diseases.

3β,5α,6β-Trihydroxycholestane is a cholesterol metabolite found mainly in animal fats and can modulate SMO activity.3β,5α,6β-Trihydroxycholestane can be used as a biomarker for schizophrenia.