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biib 037

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Aducanumab
BIIB037
T770421384260-65-4
Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brain permeability and may be used to treat Alzheimer's disease (AD).
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Aducanumab (Mouse IGG2a)
T9901A-1656
Aducanumab (Mouse IGG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta protein (Aβ). Its variable region matches that of Aducanumab, while the constant region is derived from the Mouse IGG2a sequence. Aducanumab (Mouse IGG2a) demonstrates strong selectivity for Aβ fibrils, with EC50 values of >1 μM for Aβ1-40 monomer and 0.2 nM for Aβ1-42 fibrils. This compound can be utilized in Alzheimer's disease (AD) research.
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