benzylisoquinoline

Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2 M and G1 phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent.

Berberine sulfate (Berberal) is a quaternary ammonium salt of the benzylisoquinoline alkaloid proto-berberines, which can be used in the study of type 2 diabetes mellitus, abdominal obesity and metabolism-related fatty liver disease.

Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.

Gantacurium chloride is a benzylisoquinoline alkaloid, which may be used as an adjuvant in anesthesia.

Papaveraldine is a benzylisoquinoline alkaloid that papaverine degradation product.

Protopine (Fumarine) is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.

(S)-Higenamine hydrobromide, an S-enantiomer of Higenamine, serves as the preliminary compound in benzylisoquinoline alkaloid biosynthesis. It is formed through the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) via norcoclaurine synthase (NCS)[1].

(S)-Higenamine ((S)-Norcoclaurine), the S-enantiomer vital for benzylisoquinoline alkaloid biosynthesis, is synthesized from dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) through norcoclaurine synthase (NCS) catalysis [1].

AChE BChE-IN-14 (compound 13), a benzylisoquinoline alkaloid extracted from Fissistigma polyanthum roots, demonstrates inhibitory effects on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), coupled with antioxidant properties, and is pertinent to Alzheimer's disease research [1].

(-)-O-Methyldauricine, an alkaloid featuring a benzylisoquinoline group, is derived from P. ophthalmicus. It exhibits antibacterial activity [1] [2].

Neoliensinine, a benzylisoquinoline alkaloid, effectively inhibits the contraction of isolated mesenteric vascular smooth muscle (MVSM) induced by KCl (124 mM) with an IC50 value of 2.407 μM. It can be isolated from the embryos of the traditional Chinese medicine lotus seed (Nelumbo nucifera Gaertn.).