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(2)
By Target- Autophagy
- VEGFR(2)
- FLT(1)
- PDGFR(1)
- c-Kit(1)
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Results for "
azd2171
" in TargetMol Product Catalog- Inhibitors & Agonists2
Cediranib
NSC-732208, AZD2171
T2500288383-20-0
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1 4 (IC50: 5 nM ≤3 nM), similar activity against PDGFRβ and c-Kit, selective more for VEGFR than PDGFR-α (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.
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Cediranib maleate
AZD-2171 maleate, AZD2171 maleate, AZD 2171 maleate
T2500L857036-77-2
Cediranib maleate (AZD2171 maleate) is an orally active and highly potent VEGF family receptor tyrosine kinase (VEGFR2) inhibitor that inhibits Flt1, KDR, Flt4, PDGFRα, PDGFRβ, and c-Kit, and up-regulates MHC-I through transcriptional modulation in the study of ovarian cancer.
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