artesunate

Artesunate (WR-256283) is a semisynthetic derivative of artemisinin and an inhibitor of STAT-3/EXP1. Water-soluble yet relatively unstable in neutral or acidic aqueous solutions, Artesunate is primarily employed for the treatment of malaria.

Artesunate-D4 (Standard) is a reference standard of Artesunate-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Artesunate-d4 is the deuterium-labeled form of Artesunate. Artesunate acts as an inhibitor of STAT-3 and exportin protein 1 (EXP1).

OART (Oxaliplatin-artesunate) is a ferroptosis inducer that significantly inhibits tumor cell proliferation. It promotes tumor ferroptosis by disrupting the glutathione-mediated ferroptosis defense system and enhancing the iron-dependent Fenton reaction, leading to lipid peroxidation in the cytoplasm and mitochondria. Additionally, OART increases tumor immunogenicity, transforming the tumor environment from immunosuppressive to immunosensitive. It exhibits strong tumor regression effects in tumor-bearing mouse models and can be utilized in cancer immunotherapy research.

Artesunate-D4 is the deuterium-labeled form of Artesunate. Artesunate (T0433) acts as an inhibitor of STAT-3 and exportin protein 1 (EXP1).

TCMDC-125457 can effectively induce calcium redistribution, but has little effect on inhibiting heme crystallization. When TCMDC-125457 is combined with artesunate, it can effectively treat tightly synchronized artemisinin-resistant ring-stage parasites.