apomorphine

(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor with affinity for all subtypes of dopamine D1 receptors of the D5 receptor. (-)-Apomorphine hydrochloride hydrate can be used to study mitochondrial diseases.

JNJ-37822681 has potential for the treatment of schizophrenia and bipolar disorder.JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2

Desethoxy quetiapine, an active metabolite of the atypical antipsychotic quetiapine, primarily forms through the action of the cytochrome P450 (CYP) isoform CYP3A5. This compound binds to dopamine D2 receptors with an IC50 value of 1,330 nM. In vivo, desethoxy quetiapine at dosages of 20 and 40 mg kg mitigates dopamine receptor agonist apomorphine-induced climbing behavior and ameliorates swimming deficits in mice, showcasing its potential modulatory effects on dopamine-mediated behaviors.

OPC 4392 hydrochloride acts as an agonist at presynaptic dopamine receptors (dopamine receptor) and as an antagonist at postsynaptic D2 receptors. It reverses dopamine accumulation induced by Reserpine and inhibits stereotyped and climbing behaviors in a mouse model induced by Apomorphine.

SUN90864, also known as 7-(2-Hydroxy-3-isopropylaminopropoxy)indene, is a potent β-adrenergic receptor blocker. It exhibits mild intrinsic β-sympathomimetic activity and local anesthetic effects. Additionally, SUN90864 is effective against arrhythmias induced by apomorphine and adrenaline.

BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.