antibacterial agent 32

Antibacterial agent 32 exhibits potent antimicrobial activity against E. coli strains NCTC 13351, M 50, and 7 MP, with minimum inhibitory concentration (MIC) values of 1 mcg/mL, 2 mcg/mL, and 8 mcg/mL, respectively (WO2013030733A1, example 43).

Antibiofilm agent-13 (compound 14b) is an effective broad-spectrum antibacterial agent that functions by disrupting the integrity of bacterial cell membranes. It achieves this through the degradation of transmembrane potential and increased membrane permeability, which leads to the production of intracellular ROS and the leakage of DNA and proteins, ultimately resulting in bacterial death. Antibiofilm agent-13 effectively inhibits both Gram-positive bacteria (MIC ranging from 0.5-1 μg mL) and Gram-negative bacteria (MIC ranging from 1-32 μg mL).

Antiangiogenic agent 8 (Compound 3m) functions as both an antibacterial agent and an antiangiogenic compound. It shows minimum inhibitory concentrations (MIC) of 16, 8, 4, 16, and 8 μg mL against E. coli, P. aeruginosa, B. subtilis, S. aureus, and C. glabrata, respectively, with minimum bactericidal concentrations (MBC) ranging from 32 to 64 μg mL. This compound holds potential for applications in infection control and cardiovascular disease research.

Antibacterial agent 50 (example 47) is a compound exhibiting antibacterial activity with minimum inhibitory concentration (MIC) values of 32, 64, and 128 mcg mL against E. coli strains NCTC 13351, M 50, and 7 MP, respectively [WO2013030733A1].

Antifungal agent 27 (compound 7) is a chemical compound with antifungal properties, exhibiting moderate antibacterial activity and weak antifungal activity against MRSA and C. albicans SS5314, with minimal inhibitory concentration (MIC) values of 8 and 32 μg mL, respectively [1].

Antibacterial agent 101 exhibited antibacterial and antifungal effects (MIC=4-32 μg mL).

Glicophenone, an antibacterial agent, demonstrates minimum inhibitory concentrations (MICs) of 32 μg mL against multiple strains, including MRSA OM481, MRSA OM505, MRSA OM584, MRSA OM623, and MSSA 209P [1].

Compound A11 (Antibacterial agent 86) exhibits the highest bacteriostatic activity against methicillin-resistant S. aureus, with minimum inhibitory concentration (MIC) values reaching as low as 0.00191 μg mL. This efficacy is 162 and 32 times greater than the commercial antibiotics tiamulin and retapamulin, respectively [1].

Antibacterial Agent 128, a siderophore analog-Ciprofloxacin (Ciprofloxacin) conjugate connected via a cleavable linker, demonstrates effective antibiotic properties. Specifically, it exhibits activity against P. aeruginosa and B. pseudomallei, with Minimum Inhibitory Concentration (MIC) values ranging from 0.25 to 64 μg mL and 1 to 32 μg mL, respectively [1].

Antibacterial agent 150 (compound 5g) exhibits potent activity against a wide range of bacteria, including both Gram-positive and Gram-negative species, with MIC values between 1-32 μg mL, and has enhanced the survival rates of mice infected with MRSA (Methicillin-resistant Staphylococcus aureus) [1].

IMBI (compound 32) serves as an antibacterial agent targeting quorum sensing (QS) in drug-resistant pathogens. It effectively prevents biofilm formation in Salmonella marcescens and enhances or restores susceptibility to antimicrobial drugs [1].