amphotericin b

Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species. Amphotericin B irreversibly binds to ergosterol and disrupts the integrity of cell membranes, resulting in antifungal activity.

Amphotericin B methyl ester, a derivative of the antibiotic Amphotericin B, is a cholesterol-binding compound with significant antifungal activity. It disrupts HIV-1 particle production and potently inhibits HIV-1 replication.

Amphotericin B methyl ester hydrochloride, a methyl ester derivative of the polyene antibiotic Amphotericin B (A634250), is a cholesterol-binding compound with significant antifungal activity. It disrupts HIV-1 particle production and potently inhibits HIV-1 replication [1] [2].

Amphotericin B trihydrate, a polyene antibiotic derived from Streptomyces nodosus fermenter cultures, exhibits antileishmanial properties.

L-Citronellol ((S)-(-)-beta-Citronellol) is a small molecule compound isolated from geranium with antifungal activity, affecting fungal membranes.L-Citronellol acts synergistically with amphotericin B against Candida yeast.

Amphotericin X1 is a derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, Cryptococcus neoformans 451, C.parapsilosis 937A, Aspergillus niger 57A and A.fumigatus (MICs: 1 μg/mL, 1 μg/mL, 8 μg/mL, 2

Amphocil is used to treat patients with invasive fungal infection.

MS 8209 is an amphotericin B derivative has effects on on tumor necrosis factor alpha synthesis and human immunodeficiency virus replication in macrophages.

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg/ml for combined and AmB alone, respectively) strains of A. fumigatus.

Amphotericin Methyl Ester-d3 is a deuterated compound of Amphotericin B Methyl Ester. Amphotericin B Methyl Ester has a CAS number of 36148-89-7. Amphotericin B methyl ester is the derivative of the antibiotic Amphotericin B. Amphotericin B methyl ester is the cholesterol-binding compound that possesses significant antifungal activity.