alpinia officinarum

1,7-Diphenyl-4-hepten-3-one is a compound isolated from Alpinia officinarum, which activates the Nrf2 pathway to suppress pyroptosis. It alleviates cognitive impairment and pathological damage in APP/PS1 mice and prevents oxidative stress damage while reducing levels of pyroptosis-related proteins. 1,7-Diphenyl-4-hepten-3-one enhances Aβ-induced proliferation in HT22 cells and can be used in Alzheimer’s disease research.

Alpiniaterpene A is a natural product from Alpinia officinarum.

(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) is extracted from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, and inhibits melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.

Antiviralagent 64 (Compound 12) is a diarylheptane compound isolated from *Alpinia officinarum*. In human neuroblastoma IMR-32 cells, it exhibits cytotoxicity with an IC50 of 0.23 μM. Antiviralagent 64 also demonstrates antiviral activity, effectively inhibiting RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC50 values of 13.3, 3.7, 6.3, 5.7, and <10 μg mL, respectively.