ahpc-me

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is utilized in the synthesis of ARV-771, a potent BET protein degrader. It selectively degrades BET protein in castration-resistant cells with a DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, it serves as the VHL ligand from (S,R,S)-AHPC for recruiting von Hippel-Lindau (VHL) protein.

(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.

(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, consisting of MS432 for MEK1 2 inhibitors and a VHL E3 ligase linker.

(S,R,S)-AHPC-Me-C10-NH2 is a synthesized chemical compound incorporating a VHL ligand and a linker, serving as an E3 ligase ligand-linker conjugate. It is utilized in PROTAC MS432[1].

(S,R,S)-AHPC-Me-C10-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating a VHL ligand and a linker.

(S,R,S)-AHPC-Me-C5-COOH is a synthetic E3 ligase ligand-linker conjugate composed of a VHL ligand and a linker, used in PROTAC DT2216[1].

(S,R,S)-AHPC-Me-C7 ester is an E3 ligase ligand-linker conjugate used to synthesize BCL-XL PROTAC degraders[1].

6-Aminocaproic acid-(S,R,S)-AHPC-Me serves as a ligand and linker for the E3 ubiquitin ligase in PROTACs, facilitating the synthesis of PVD-06 for research in oncology.

Amino-PEG4-(S,R,S)-AHPC-Me is a ligand+linker conjugate for E3 ubiquitin ligases. It is utilized in the synthesis of PROTACNR-V04.

trans-(S,R,S)-AHPC-Me-Amide-cyclohexane-pyrimidine-Cl is an E3 ligase ligand-Linker conjugate that is utilized in the synthesis of PROTACs, such as PROTAC BRM BRG1 degrader-2.

(S,R,S)-AHPC-Me-amide-C9-acid is an E3 ligase ligand-linker conjugate utilized in synthesizing PROTACSMARCA2 degrader-31.

(S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide comprises a VHL ligand for recruiting E3 ubiquitin ligases and a PROTAC linker. This compound is used in synthesizing PROTACs such as MS934. MS934 represents a novel and improved VHL-recruiting MEK1 2 PROTAC degrader.

(S)-(S,R,S,R)-AHPC-Me-N3 is an E3 ligase ligand for PROTACSMARCA2 degrader-32, utilized in the synthesis of PROTACs.

(S,R,S)-AHPC-Me-amide-C-O-C5-Br is a compound that includes a VHL ligand for recruiting E3 ubiquitin ligase, along with a linker. This compound is utilized in the synthesis of various PROTAC molecules, such as [ERD-308].

(S,R,S)-AHPC-Me-N-Boc-7-aminoheptanoic acid is a conjugate serving as an E3 ligase ligand and linker, specifically used for the synthesis of PROTACdTAGV-1 TFA.

(S,R,S)-AHPC-Me-8-Sulfamoyloctanoic acid is an E3 ubiquitin ligase ligand-linker conjugate (E3 ligase ligand-linker conjugate) that can be utilized in the synthesis of XZ338.

(S,R,S)-AHPC-Me-decanedioic acid is a ligand-linker conjugate for E3 ligases, intended for PROTAC synthesis.

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthetic E3 ligase ligand-linker conjugate composed of a VHL ligand and a linker, utilized in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3.

(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

SMARCA2 4-ligand-Linker Conjugate-2 is an E3 ubiquitin ligase ligand-linker conjugate.

Me-(S,R,S)-AHPC-CO-CH2-Br is an E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-linker conjugate). It is utilized in the synthesis of JNJ-1013.

Me-(S,R,S)-AHPC-PEG2-OTs is a conjugate of E3 ligase ligand and linker (E3 Ligase Ligand-Linker Conjugates) utilized in the synthesis of PROTAC HIF-1α degrader-1.

Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH is a compound consisting of an E3 ligase ligand and a linker, suitable for the synthesis of PROTAC degrader MS4322.

Me-(S,R,S)-AHPC-CO-C5-N3 is an E3 ligase ligand-linker conjugate composed of a VHL ligand and a linker. It is utilized in the synthesis of PROTACs, such as [PROTACCG167].